They offer a promising new therapeutic angle to touch on pathogenic mechanisms of coronary disease directly. Necrosis – a primary hallmark of clinical atherosclerosis – was recently linked to immunity. Necrotic tumor cell-derived epitopes are able to elicit a solid cytolitic immune response, allowing tumor elimination. Key for this finding is a process called cross-presentation: direct display of exogenous antigen on an MHCI molecule accompanied by a powerful CD8. Identification of their individual counterparts emphasizes the importance of cross-presentation in human health and disease.In a mature atherosclerotic plaque, necrotic cell or tissue-associated epitopes, dendritic cells and CD8 are present and in close contact abundantly.