A pigmented lesion on the sole Dermoscopy pays to in evaluating small pigmented lesions on the sole, but some lesions might show areas of asymmetric homogenous pigment, prompting biopsy. Case presentation A 39-year-old woman noted an asymmetrical dark mole over the medial aspect of her right posterior sole . The mole had made an appearance over the prior 12 a few months and measured 3 mm in size. Dermoscopy demonstrated a lattice-like pigment network with little brownish globules. Excision biopsy revealed a well developed epidermal rete ridge program with nests of melanocytes at their guidelines and also within the superficial dermis. The junctional and superficial dermal nests had been deeply pigmented, but there was no atypia ..Blockade of interleukin-17 receptor A with brodalumab has been shown to bring about reversal of the psoriatic phenotype and gene expression patterns, with many keratinocyte-expressed genes responding within a week; a return to nonlesional levels of gene expression offers been seen by 2 weeks.12 To confirm the results of early clinical studies with brodalumab,13,14 we conducted the AMAGINE-2 and AMAGINE-3 trials. Patients with medical conditions that could potentially prevent them from completing the analysis or that could hinder the interpretation of outcomes weren’t included . Medicines with the potential to confound efficacy were prohibited; patients who experienced received specified medicines could participate after a washout period .