‘Our discovery suggests a new pathogenic system that may operate in a wider selection of neurodegenerative disorders, the genetics of which remain very poorly understood generally,’ concluded Sharifi. Deficiency of terminal ADP-ribose proteins glycohydrolase TARG1/C6orf130 in neurodegenerative disease.. ADP-ribose plays key role in repairing cellular DNA damage Attaching chains of the small molecule ADP-ribose to proteins is important for a cell's survival and the restoration of DNA damage, making this process a promising focus on for the advancement of new cancer medications.O’Connell, Ph.D., Da-Wei Gong, Ph.D., Richard J. Breyer, III, M.D., Alice S. Ryan, Ph.D., John C. McLenithan, Ph.D., Alan R. Shuldiner, M.D., Carole Sztalryd, Ph.D., and Coleen M. Damcott, Ph.D.: Null Mutation in Hormone-Sensitive Lipase Risk and Gene of Type 2 Diabetes Both surplus and insufficient storage of lipids in white adipose tissue are associated with dyslipidemia, insulin resistance, and an increased risk of type 2 diabetes; thus, maintaining normal white-adipose-cells function is critical for whole-body insulin sensitivity and energy homeostasis.1 Hormone-sensitive lipase , encoded by LIPE, can be an intracellular lipase with many neutral lipid substrates, including triglycerides, diglycerides, monoglycerides, cholesterol esters, and retinyl esters.